Leucovorin
Name: Leucovorin
Pharmacology
Mechanism of Action
Serves as a cofactor supplement to counteract folic acid antagonists such as methotrexate; leucovorin is an active metabolite of folic acid
Displaces methotrexate from intracellular binding sites and restores the folate required for DNA/RNA synthesis
In methanol toxicity it serves as a tetrahydrofolate source to help the body eliminate the formic acid resulting from methanol's toxicity
Pharmacokinetics
Distribution: all body tissues, predominantly in liver
Metabolism: Rapidly converted to THF derivatives
Excretion: Urine (primarily); feces
Half-life elimination: 4-8hr
Peak plasma time: 2 hr (PO); 10 min (as folate); 1 hr (as tetrahydrofolate)
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
An overdose of leucovorin is not likely to cause life-threatening symptoms. However, leucovorin overdose can make other medications less effective.
What should I avoid while taking leucovorin?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.