Klor-Con M

The administration of oral potassium salts to persons with normal excretory mechanisms for potassium rarely causes serious hyperkalemia. However, if excretory mechanisms are impaired or if potassium is administered too rapidly intravenously, potentially fatal hyperkalemia can result (see CONTRAINDICATIONS and WARNINGS). It is important to recognize that hyperkalemia is usually asymptomatic and may be manifested only by an increased serum potassium concentration (6.5-8.0 mEq/L) and characteristic electrocardiographic changes (peaking of T-waves, loss of P-waves, depression of S-T segment, and prolongation of the QT-interval). Late manifestations include muscle paralysis and cardiovascular collapse from cardiac arrest (9-12 mEq/L).

Treatment measures for hyperkalemia include the following:

1. Patients should be closely monitored for arrythmias and electrolyte changes.
2. Elimination of foods and medications containing potassium and of any agents with potassium-sparing properties such as potassium-sparing diuretics, ARBS, ACE inhibitors, NSAIDs, certain nutritional supplements and many others.
3. Intravenous calcium gluconate if the patient is at no risk or low risk of developing digitalis toxicity.
4. Intravenous administration of 300 to 500 mL/hr of 10% dextrose solution containing 10-20 units of crystalline insulin per 1,000 mL.
5. Correction of acidosis, if present, with intravenous sodium bicarbonate.
6. Use of exchange resins, hemodialysis, or peritoneal dialysis.

In treating hyperkalemia, it should be recalled that in patients who have been stabilized on digitalis, too rapid a lowering of the serum potassium concentration can produce digitalis toxicity.

The extended release feature means that absorption and toxic effects may be delayed for hours. Consider standard measures to remove any unabsorbed drug.

Klor-Con® M20 Extended-release Tablets, 1500 mg of potassium chloride (20 mEq of potassium) are available in bottles of 90 (NDC 0245-0058-90); bottles of 100 (NDC 0245-0058-11); bottles of 500 (NDC 0245-0058-15); bottles of 1000 (NDC 0245-0058-10); and cartons of 100 for unit dose dispensing (NDC 0245-0058-01). Klor-Con® M20 tablets are white, oblong, imprinted KC M20 and scored for flexibility of dosing.

Klor-Con® M15 Extended-release Tablets, 1125 mg of potassium chloride (15 mEq of potassium) are available in bottles of 100 (NDC 0245-0150-11); bottles of 1000 (NDC 0245-0150-10); and cartons of 100 for unit dose dispensing (NDC 0245-0150-01). Klor-Con® M15 tablets are white, oblong, imprinted M 15 and scored for flexibility of dosing.

Klor-Con® M10 Extended-release Tablets, 750 mg of potassium chloride (10 mEq of potassium) are available in bottles of 90 (NDC 0245-0057-90); bottles of 100 (NDC 0245-0057-11); bottles of 1000 (NDC 0245-0057-10); and cartons of 100 for unit dose dispensing (NDC 0245-0057-01). Klor-Con® M10 tablets are white, oblong and imprinted KC M10.

Keep tightly closed. Store at 20-25°C (68-77°F). Excursions permitted to 15-30°C (59-86°F). [See USP Controlled Room Temperature.]

Manufactured by
UPSHER-SMITH LABORATORIES, INC.
Maple Grove, MN 55369
US Patent 6,780,437

Certain manufacturing operations have been performed by other firms.

Revised 1214

Potassium is a mineral that is found in many foods and is needed for several functions of your body, especially the beating of your heart.

Potassium chloride is used to prevent or to treat low blood levels of potassium (hypokalemia).

Potassium levels can be low as a result of a disease or from taking certain medicines, or after a prolonged illness with diarrhea or vomiting.

• Potassium chloride tablets are used to prevent and treat low blood levels of potassium (this is also called hypokalemia).
• Tablets are designed to release potassium chloride slowly over a period of time.