Ixazomid

Ixazomid is part of the drug class:

• OTHER ANTINEOPLASTIC AGENTS

Ixazomib may cause serious side effects, including:

• Low platelet counts (thrombocytopenia). Low platelet counts are common with ixazomib, and can sometimes be serious. You may need platelet transfusions if your counts are too low. Tell your healthcare provider if you have any signs of low platelet counts, including bleeding and easy bruising.
• Stomach and intestinal (gastrointestinal) problems. Diarrhea, constipation, nausea, and vomiting are common with ixazomib, and can sometimes be severe. Call your healthcare provider if you get any of these symptoms and they do not go away during treatment with ixazomib. Your healthcare provider may prescribe medicine to help treat your symptoms.
• Nerve problems. Nerve problems are common with ixazomib and may also be severe. Tell your healthcare provider if you get any new or worsening symptoms, including:
  • tingling
  • numbness
  • pain
  • a burning feeling in your feet or hands 
  • weakness in your arms or legs
• Swelling. Swelling is common with ixazomib and can sometimes be severe. Tell your healthcare provider if you develop swelling in your arms, hands, legs, ankles, or feet, or if you gain weight from swelling.
• Skin reactions. Tell your healthcare provider if you get a new or worsening rash.
• Liver problems. Tell your healthcare provider if you get these signs of a liver problem:
  • yellowing of your skin or the whites of your eyes
  • pain in your right upper stomach-area Back pain is also common with ixazomib.

These are not all the possible side effects of ixazomib. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. 

• Take ixazomib exactly as your healthcare provider tells you to take it. Do not change your dose or stop taking ixazomib without talking to your healthcare provider first.
• Ixazomib is taken in “cycles.” Each cycle lasts 4 weeks (28 days).
  • The usual dose of ixazomib is 1 capsule taken 1 time each week, on the same day of the week for the first 3 weeks of each cycle. 
  • Take each dose of ixazomib at about the same time of day. 
  • Take Revlimid (lenalidomide) and dexamethasone exactly as your healthcare provider tells you to. 
  • Your healthcare provider will do blood tests during treatment with ixazomib to check for side effects. 
  • Your healthcare provider may change your dose or stop ixazomib, Revlimid (lenalidomide), or dexamethasone if you have side effects.
• Take ixazomib at least 1 hour before or at least 2 hours after food. 
• On the days that you take both ixazomib and dexamethasone, do not take ixazomib and dexamethasone at the same time. Take dexamethasone with food. 
• Swallow ixazomib capsules whole with water. Do not crush, chew or open the capsule. 
• Avoid direct contact with the capsule contents. If you accidentally get powder from the ixazomib capsule on your skin, wash the area well with soap and water. If you accidentally get powder from the ixazomib capsule in your eyes, flush your eyes well with water.
• If you miss a dose of ixazomib, or if you are late taking a dose, take the dose as long as the next scheduled dose is more than 3 days (72 hours) away. Do not take a missed dose of ixazomib if it is within 3 days (72 hours) of your next scheduled dose. 

If you vomit after taking a dose of ixazomib, do not repeat the dose. Take your next dose of ixazomib on the next scheduled day and time.

If you take more ixazomib than your healthcare provider tells you to take, call your healthcare provider right away or go to the nearest hospital emergency room.