Iscar quercus special injection

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

Treatment with ISCAR MALI SPECIAL 25mg and ISCAR QUERCUS SPECIAL 25mg is administered in two distinct phases:

Induction Phase

Start with 1 box of Series 0 . Beginning with the 0.05mg tincture/ml ampule inject 3 times weekly, increasing the strength sequentially. Repeat with a second box of Series 0. If well tolerated by the patient, treatment can be instituted with ISCAR MALI SPECIAL 25mg or ISCAR QUERCUS SPECIAL 25mg.

Maintenance Phase:

The maintenance phase has been reached with the switch to ISCAR MALI SPECIAL 25mg or ISCAR QUERCUS SPECIAL 25mg, which is injected 3 times weekly subcutaneously. Progress should be monitored on a regular basis. With marked local reactions (more than 2"/5cm in diameter) and/or temperature reactions above 100.4 °F (38 °C), treatment should be stopped until the symptoms have subsided. Afterwards, treatment is resumed with a lower dose of ISCAR SPECIAL. This may be done by reducing the frequency of injection or by using a fraction of an ampule.

During the first year of treatment with ISCAR SPECIAL, it is recommended to continue treatment without injec-tion-free intervals. After the first year of treatment, the physician may recommend a 1-week injection-free interval following every sequence of 14 injections if progress is satisfactory.

Individual Reaction:   This may be recognized by at least one of the following:

• Objective and subjective improvement in general condition-- including improved appetite and weight gain, better sleep, reduction in pain, patient feeling less tired, lightening of depressive mood and stimulation of eliminatory processes.
• Improvement in immunological status-- normal leukocyte and/or lymphocyte counts are desirable. Eosinophilia with absence of allergic symptomatology is commonly seen. Immunological tests can help in establishing optimum dosage.
• Temperature reaction-- these may vary, and include:
  
  1. Temperature rises once, a few hours after the injection;
  2. Re-establishment of physiological difference between morning and evening temperatures of at least 0.9 °F (0.5 °C);
  3. Rise in mean diurnal temperature.
• Local inflammatory reaction-- reddening around the injection site to a maximum of 2" (5 cm) in diameter.

Frequency of Injections and Treatment Intervals:

All types of ISCAR are usually administered 3 times weekly. The best time tends to be in the mornings, or when the body temperature naturally rises.

After one year of treatment, if progress is satisfactory, the physician may recommend a 1-week injection-free interval following every sequence of 14 injections.

Important:     Although the above recommendations reflect common practice, the physician may recommend different dosage frequencies.

Method of Injection:

Injections of the contents of a 1-ml ampule of all types of should be given sub-cutaneously. ISCAR works systemically, so injections are often given in the abdominal region or thigh. Some researchers believe that there may be a local effect as well, so the physician may recommend administering the injection in the vicinity of the tumor. Irradiated areas and inflamed skin areas should be avoided. The distance from the tumor should be 1.2"-1.6" (3-4 cm).

Each package contains 7 × 1-ml ampules. When ordering, please be sure to specify the "host" type and strength desired.

STORAGE

Store at controlled room temperature (15-30 °C / 60-85 °F) away from direct sunlight, except for the "Special" which should be stored in the refrigerator (4-8 °C / 39-46 °F). To avoid local irritation, hold the ampule in your hand briefly to warm up the liquid before injecting.