Iopidine Eye

IOPIDINE® 0.5% Ophthalmic Solution contains apraclonidine hydrochloride, an alpha adrenergic agonist, in a sterile isotonic solution for topical application to the eye. Apraclonidine hydrochloride is a white to off-white powder and is highly soluble in water. Its chemical name is 2-[(4-amino-2,6 dichlorophenyl) imino]imidazolidine monohydrochloride with an empirical formula of C9H11Cl3N4 and a molecular weight of 281.57. The chemical structure of apraclonidine hydrochloride is:

Each mL of IOPIDINE 0.5% Ophthalmic Solution contains: Active: apraclonidine hydrochloride 5.75 mg equivalent to apraclonidine base 5 mg; . Inactives: sodium chloride, sodium acetate, sodium hydroxide and/or hydrochloric acid (pH 4.4-7.8), purified water and benzalkonium chloride 0.01% (preservative)

Not for injection or oral ingestion. FOR TOPICAL OPHTHALMIC USE ONLY.

You should not use this medication if you are allergic to apraclonidine or to clonidine (Catapres).

Do not use apraclonidine ophthalmic if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

Before using apraclonidine ophthalmic, tell your doctor if you have:

• kidney disease;
• liver disease;
• heart disease or high blood pressure;
• a history of fainting or low blood pressure.

If you have any of these conditions, you may need a dose adjustment or special tests to safely use apraclonidine ophthalmic.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether apraclonidine ophthalmic passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Since apraclonidine ophthalmic is usually given as needed by a healthcare professional, it is not likely that you will miss a dose.

If you are on a dosing schedule and you forget to use your medication, apply the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.

Avoid using other medications in your eyes during treatment with apraclonidine unless your doctor has told you to.

• Glaucoma