Imiglucerase

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Other drugs may interact with imiglucerase, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

1-10%

Hypersensitivity with infusion (6.6%)

Nausea, abdominal pain, vomigin, diarrhea (1.5%)

Rash (1.5%)

Fatigue (1.5%)

Headache (1.5%)

Fever (1.5%)

Dizziness (1.5%)

Chills (1.5%)

Backache (1.5%)

Tachycardia (1.5%)

<1%

Discomfort

Pruritus

Burning

Swelling

Sterile abscess at site of venipuncture

Pulmonary hypertension

Pneumonia

You should not use imiglucerase if you are allergic to it.

To make sure imiglucerase is safe for you, tell your doctor if you have:

• a breathing problem such as pneumonia or pulmonary hypertension.

FDA pregnancy category C. It is not known whether imiglucerase will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether imiglucerase passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Imiglucerase should not be given to a child younger than 2 without a doctor's advice.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during or shortly after the injection. Tell your caregiver right away if you feel dizzy, itchy, light-headed, sweaty, or have chest pain, cough, trouble breathing, or flushing (warmth, redness, or tingly feeling).

Call your doctor at once if you have:

• fever, chills, cough with yellow or green mucus;

• stabbing chest pain, wheezing, feeling short of breath; or

• worsening or no improvement in your Gaucher disease symptoms.

Common side effects may include:

• stomach pain, nausea, vomiting, diarrhea;

• fast heartbeats;

• headache, dizziness;

• back pain;

• fever, chills, tired feeling;

• mild rash; or

• itching, burning, swelling, or other discomfort around the IV needle.

• It is used to treat Gaucher's disease.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

• Enzyme

Significant improvement in symptoms: Hepatosplenomegaly and hematologic abnormalities: Within 6 months; Improvement in bone mineralization: Noted at 80 to 104 weeks of therapy

Half-Life Elimination

3.6 to 10.4 minutes

There are no dosage adjustments provided in the manufacturer’s labeling.

Reconstitute 400 unit vial with 10.2 ml SWFI resulting in a 40 units/mL concentration. Slight flocculation (thin translucent fibers) may appear after dilution; do not use if discolored or opaque particles appear. Withdraw appropriate volume of reconstituted solution and further dilute in NS to a final volume of 100 to 200 mL.

Data not available