Icatibant (Subcutaneous Route)

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of icatibant injection in the elderly.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Captopril

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For injection dosage form:
  • For attacks of hereditary angioedema:
    • Adults—30 milligrams (mg) or 3 milliliters (mL) injected under your skin. Your doctor may give you or tell you to use an additional dose after 6 hours if your symptoms continue or come back. Do not use more than 3 doses in 24 hours.
    • Children—Use and dose must be determined by your doctor.

Call your doctor or pharmacist for instructions.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

You may store this medicine in the refrigerator or at room temperature. Store the medicine in the original carton until you are ready to use it. Do not freeze.

Throw away used prefilled syringe with the needle attached in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.