Hyoscyamine, methenamine, methylene blue, and phenyl salicylate

Hyoscyamine produces many effects in the body, including relief from muscle spasms.

Methenamine and methylene blue work as mild antiseptics that fight bacteria in the urine and bladder.

Phenyl salicylate is a mild pain reliever.

Hyoscyamine, methenamine, methylene blue, and phenyl salicylate is a combination medicine used to treat bladder irritation (pain, burning, inflammation) caused by urinary tract infection. This medication is also used to prevent bladder discomfort during a medical procedure.

Hyoscyamine, methenamine, methylene blue, and phenyl salicylate may also be used for purposes not listed in this medication guide.

You should not use this medicine if you are allergic to hyoscyamine, methenamine, methylene blue, or phenyl salicylate.

To make sure this medicine is safe for you, tell your doctor if you have:

• heart disease;

• a heart rhythm disorder;

• congestive heart failure;

• coronary heart disease;

• a heart valve disorder;

• glaucoma;

• an enlarged prostate or bladder obstruction;

• myasthenia gravis;

• an ulcer or obstruction in your stomach; or

• if you are allergic to belladonna (Donnatal and others).

It is not known whether this medication will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Hyoscyamine, methenamine, methylene blue, and phenyl salicylate can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

This medicine should not be given to a child younger than 7 years old.

Older adults may be more likely to have side effects from this medication.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Usual Adult Dose for Urinary Tract Infection:

Hyoscyamine/methenamine/methylene blue/phenyl salicylate 0.06 mg-81.6 mg-10.8 mg-36.2 mg oral enteric coated tablet:
1 tablet orally 4 times/day.

Hyoscyamine/methenamine/methylene blue/phenyl salicylate 0.12 mg-100 mg-10.8 mg-40 mg oral capsule:
1 capsule orally 4 times/day.

hyoscyamine/methenamine/methylene blue/phenyl salicylate 0.12 mg-118 mg-10 mg-36 mg oral capsule:
1 capsule orally 4 times/day.

Hyoscyamine/methenamine/methylene blue/phenyl salicylate 0.12 mg-81.6 mg-10.8 mg-36.2 mg oral enteric coated tablet:
1 tablet orally 4 times/day.

Usual Pediatric Dose for Urinary Tract Infection:

Hyoscyamine 0.06 mg/methenamine 81.6 mg/methylene blue 10.8 mg/phenyl salicylate 36.2 mg enteric coated oral tablets:
12 yrs or older: 1 tablet orally 4 times/day.

Many drugs can interact with this medicine. Not all possible interactions are listed here. Also, hyoscyamine can make it harder for your body to absorb other medications you take by mouth. Tell your doctor about all your medications and any you start or stop using, especially:

• neostigmine, pyridostigmine;

• bladder or urinary medicines such as darifenacin, fesoterodine, oxybutynin, tolterodine, solifenacin;

• bronchodilators such as ipratropium or tiotropium;

• cold or allergy medicine that contains an antihistamine;

• a diuretic or "water pill";

• an MAO inhibitor--furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, tranylcypromine;

• medication to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel syndrome;

• medication to treat gout, kidney stones, or an electrolyte imbalance (such as low levels of potassium);

• medication to treat symptoms of Alzheimer's disease or Parkinson's disease;

• narcotic pain or cough medication--codeine, fentanyl, hydrocodone, hydromorphone, methadone, morphine, oxycodone, propoxyphene, and others; or

• sulfa drugs.

This list is not complete and many other drugs can interact with hyoscyamine, methenamine, methylene blue, and phenyl salicylate. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.