Fosaprepitant Injection

Fosaprepitant injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. It is usually given by intravenous infusion over 20 to 30 minutes, beginning about 30 minutes before the start of chemotherapy.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before using fosaprepitant injection,

• tell your doctor and pharmacist if you are allergic to fosaprepitant, aprepitant (Emend), any other medications, or any of the ingredients in fosaprepitant injection. Ask your pharmacist for a list of the ingredients.
• tell your doctor if you are taking pimozide (Orap). Your doctor will probably tell you not to use fosaprepitant injection if you are taking this medication.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); certain antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral); benzodiazepines such as alprazolam (Xanax), midazolam (Versed), and triazolam (Halcion); certain cancer chemotherapy medications such as ifosfamide (Ifex), vinblastine, and vincristine (Marquibo); carbamazepine (Tegretol, Teril); clarithromycin (Biaxin, in Prevpac); diltiazem (Cardizem, Dilacor); certain HIV protease inhibitors such as nelfinavir (Viracept) and ritonavir (Norvir); hormonal contraceptives (birth control pills, patches, rings, and injections); nefazodone; oral steroids such as dexamethasone and methylprednisolone (Medrol); phenytoin (Dilantin, Phenytek); rifampin (Rifadin, Rimactane); and troleandomycin (TAO, no longer available in the U.S.). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with fosaprepitant, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
• tell your doctor if you have or have ever had liver disease.
• tell your doctor if you are pregnant or plan to become pregnant. If you are taking birth control medications during treatment with fosaprepitant you should also use an additional method of birth control to avoid pregnancy during treatment with fosaprepitant and for one month after your final dose. Talk to your doctor about birth control methods while you are receiving fosaprepitant and after treatment. If you become pregnant while using fosaprepitant, call your doctor.
• tell your doctor if you are breastfeeding.

Unless your doctor tells you otherwise, continue your normal diet.

Keep all appointments with your doctor.

Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.