Ferric Hexacyanoferrate

• It is used to get rid of extra cesium or thallium from the body.

• If you have an allergy to ferric hexacyanoferrate or any other part of ferric hexacyanoferrate.
• If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
• If you are breast-feeding or plan to breast-feed.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

Use ferric hexacyanoferrate as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Take this medicine with food.
• Capsules may be opened and contents mixed with food or liquid.

What do I do if I miss a dose?

• Take a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not take 2 doses at the same time or extra doses.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

(FER ik hex a SYE an oh fer ate)

• Ferric (III) Hexacyanoferrate (II)
• Ferric Ferrocyanide
• Insoluble Prussian Blue
• Prussian Blue

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Capsule, Oral:

Radiogardase: 0.5 g

Binds to cesium and thallium isotopes in the gastrointestinal tract following their ingestion or excretion in the bile; reduces their gastrointestinal reabsorption (enterohepatic circulation)

Absorption

Ferric hexacyanoferrate: Oral: None

Excretion

Ferric hexacyanoferrate: Feces (99%, unchanged) (Radiogardase, 2008)

Half-Life Elimination

Cesium-137: Effective: Adults: 80 days, decreased by 69% with ferric hexacyanoferrate; adolescents: 62 days, decreased by 46% with ferric hexacyanoferrate; children: 42 days, decreased by 43% with ferric hexacyanoferrate

Nonradioactive thallium: Biological: 8 days; with ferric hexacyanoferrate: 3 days

Frequency not always defined.

Gastrointestinal: Constipation (24%), fecal discoloration (blue), gastric distress

Endocrine & metabolic: Hypokalemia (7%)

Data not available.
This drug may be less effective in patients with hepatic impairment due to decreased excretion of cesium and thallium in the bile.