Epiduo (as a combination product containing Adapalene, Benzoyl Peroxide)

Adapalene is used to treat acne. Adapalene is in a class of medications called retinoid-like compounds. It works by stopping pimples from forming under the surface of the skin.

Adapalene may cause side effects. The following symptoms are likely to affect your skin during the first 2-4 weeks of treatment. Tell your doctor if any of these symptoms are severe or do not go away:

• redness
• scaling
• dryness
• burning or stinging
• itching

Medications that are similar to adapalene have caused tumors in laboratory animals who were given the medications and exposed to real or artificial sunlight. It is not known whether adapalene increases the risk of tumors in humans. Protect yourself from sunlight and sunlamps while taking adapalene, and talk to your doctor about the risks of taking this medication.

Adapalene may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

You should not swallow adapalene. If you swallow adapalene, call your local poison control center at 1-800-222-1222.