Dytan-D

Name: Dytan-D

What should I discuss with my healthcare provider before taking Dytan-D (diphenhydramine and phenylephrine)?

You should not use this medicine if you are allergic to diphenhydramine or phenylephrine.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have other medical conditions, especially:

  • asthma or COPD, cough with mucus, or cough caused by smoking, emphysema, or chronic bronchitis;

  • kidney or liver disease;

  • high blood pressure, heart disease;

  • enlarged prostate, urination problems;

  • glaucoma;

  • diabetes; or

  • a thyroid disorder.

It is not known whether diphenhydramine and phenylephrine will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant.

It is not known whether diphenhydramine and phenylephrine passes into breast milk or if it could affect a nursing baby. Antihistamines and decongestants may also slow breast milk production. Ask a doctor before using this medicine if you are breast-feeding.

Artificially sweetened liquid medicine may contain phenylalanine. Check the medication label if you have phenylketonuria (PKU).

What should I avoid while taking Dytan-D (diphenhydramine and phenylephrine)?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Drinking alcohol with this medicine can cause side effects.

Ask a doctor or pharmacist before using any other cold, allergy, or sleep medicine. Many combination medicines contain diphenhydramine (Benadryl) or phenylephrine. Taking certain products together can cause you to get too much of this medicine.

For Healthcare Professionals

Applies to diphenhydramine / phenylephrine: oral disintegrating strip, oral liquid, oral suspension extended release, oral tablet chewable extended release

Cardiovascular

Cardiovascular side effects have included hypotension, palpitations, tachycardia, and extrasystole.[Ref]

Hematologic

Hematologic side effects have included hemolytic anemia, agranulocytosis, and thrombocytopenia.[Ref]

Nervous system

Nervous system side effects have included sleepiness, sedation, dizziness, disturbed coordination, fatigue, confusion, restlessness, excitation, nervousness, tremor, irritability, insomnia, euphoria, paresthesia, headache, vertigo, tinnitus, acute labyrinthitis, neuritis, and convulsions.[Ref]

Ocular

Ocular side effects have included blurred vision and diplopia.[Ref]

Gastrointestinal

Gastrointestinal side effects have included epigastric distress, anorexia, nausea, vomiting, diarrhea, and constipation.[Ref]

Genitourinary

Genitourinary side effects have included urinary frequency, difficult urination, urinary retention, and early menses.[Ref]

Hypersensitivity

Hypersensitivity side effects have included urticaria, drug rash, anaphylactic shock, and photosensitivity.[Ref]

General

General side effects have included chills, excessive perspiration, and dryness of nose, throat and mouth.[Ref]

Some side effects of Dytan-D may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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