Difluprednate

Difluprednate may be found in some form under the following brand names:

• Durezol

Postoperative Ocular Inflammation and Pain

Treatment of inflammation and pain associated with ocular surgery.1 2

Storage

Ophthalmic

15–25°C.1 Do not freeze; protect from light.1 Keep bottle in protective carton when not in use.1

• Importance of learning and adhering to proper administration techniques to avoid contamination of the tip of the container.1

• Importance of not wearing contact lenses during therapy unless specifically directed by a clinician.1 3

• Importance of administering other topical ophthalmic preparations 10 minutes apart from difluprednate administration.3

• Risks of adverse ocular effects, wound healing complications, and ocular infections.1 3 Consult a clinician if pain develops or if redness, itching, or inflammation worsens.1

• Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.1

  Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses.1

• Importance of informing patients of other important precautionary information.1 (See Cautions.)

• Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.
• Use care when driving or doing other tasks that call for clear eyesight.
• Do not use longer than you have been told by the doctor.
• Long-term use may raise the chance of cataracts or glaucoma. Talk with the doctor.
• Have your eye pressure checked if you are on difluprednate for a long time. Talk with your doctor.
• Bright lights may bother you. Wear sunglasses.
• Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine while you are pregnant.
• Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Eye irritation.
• Headache.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

(dye floo PRED nate)

Refer to adult dosing.

There are no dosage adjustments provided in the manufacturer’s labeling; however, systemic absorption is limited.

Ophthalmic: Wash hands prior to use and avoid touching tip of dropper. Remove contact lenses prior to use. Do not reinsert contact lenses within 10 minutes of difluprednate eye drops. The use of the same bottle for both eyes is not recommended in surgical patients.

Store at 15°C to 25°C (59°F to 77°F); do not freeze. Protect from light.

Caution is recommended. Excreted into human milk: Unknown Excreted into animal milk: Data not available Comments: -The effects in the nursing infant are unknown. -Systemically administered corticosteroids appear in human milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other untoward effects.