Crisaborole

Name: Crisaborole

Crisaborole Interactions

This is not a complete list of Crisaboroledrug interactions. Ask your doctor or pharmacist for more information.

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

Crisaborole

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Topical

Ointment

20 mg /1 g

Eucrisa

Anacor Pharmaceuticals Inc.

How is this medicine (Crisaborole) best taken?

Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Do not take crisaborole by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
  • Do not put in the vagina.
  • Wash your hands before and after use. Do not wash your hands after use if putting this on your hand.
  • Clean affected part before use. Make sure to dry well.
  • Put a thin layer on the affected part.

What do I do if I miss a dose?

  • Put on a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not put on 2 doses or extra doses.

How do I store and/or throw out Crisaborole?

  • Store at room temperature.
  • Keep lid tightly closed.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

Pharmacologic Category

  • Phosphodiesterase-4 Enzyme Inhibitor, Topical
  • Topical Skin Product

Dosing Adult

Atopic dermatitis: Topical: Apply a thin film to affected area(s) 2 times daily.

Dosing Renal Impairment

There are no dosage adjustments provided in the manufacturer's labeling.

Storage

Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F).

Drug Interactions

Riociguat: Crisaborole may enhance the hypotensive effect of Riociguat. Management: Riociguat is contraindicated with nonselective phosphodiesterase (PDE) inhibitors and PDE type 5 inhibitors. Other types of PDE inhibitors are not contraindicated, but caution is advised and patients should be monitored for hypotension. Monitor therapy

Usual Pediatric Dose for Atopic Dermatitis

2 years or older: Apply a thin layer to the affected area(s) twice a day

Use: For the topical treatment of mild to moderate atopic dermatitis

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