Chlorambucil (Oral Route)

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies have not been performed on the relationship of age to the effects of chlorambucil in the pediatric population. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of chlorambucil in the elderly. However, elderly patients are more likely to have kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving this chlorambucil.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Bone marrow depression or
• Head injury or
• Seizures, history of—Use with caution. May make these conditions worse.

• Gout or
• Kidney stones, history of—Chlorambucil may increase levels of uric acid in the body, which can cause gout or kidney stones.

• Infection—May decrease your body's ability to fight infection.

• Kidney disease (e.g., nephrotic syndrome)—Use with caution. May increase risk for seizures.

• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  • For chronic lymphatic leukemia and other types of lymphoma:
    • Adults—Dose is based on body weight and must be determined by your doctor. The dose is usually 0.1 milligram (mg) per kilogram (kg) of body weight per day, taken as a single dose, for 3 to 6 weeks.
    • Children—Use and dose must be determined by your doctor.
  • For treatment of Hodgkin's disease:
    • Adults—Dose is based on body weight and must be determined by your doctor. The dose is usually 0.2 milligram (mg) per kilogram (kg) of body weight per day, taken as a single dose, for 3 to 6 weeks.
    • Children—Use and dose must be determined by your doctor.