Cetrorelix

Cetrorelix is part of the drug class:

• Anti gonadotropin releasing hormones

Cetrorelix is available in the following forms:

• Injectable Solution

• If you have an allergy to cetrorelix or any other part of cetrorelix.
• If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
• If you have kidney disease.
• If you are pregnant or may be pregnant. Do not take this medicine if you are pregnant.
• If you are breast-feeding. Do not breast-feed while you take cetrorelix.

This is not a list of all drugs or health problems that interact with this medicine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take cetrorelix with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Kit, Subcutaneous:

Cetrotide: 0.25 mg [contains mannitol]

• Cetrotide

0.25 mg dose: 2 hours; 3 mg dose: 1 hour

Time to Peak

1 to 2 hours

Controlled ovarian stimulation: Inhibits premature luteinizing hormone (LH) surges in women undergoing controlled ovarian stimulation.

Controlled ovarian stimulation in conjunction with gonadotropins (FSH, hMG): Female: SubQ:

Single-dose regimen: 3 mg given when serum estradiol levels show appropriate stimulation response, usually stimulation day 7 (range: days 5 to 9). If hCG is not administered within 4 days, continue cetrorelix at 0.25 mg/day until hCG is administered.

Multiple-dose regimen: 0.25 mg once daily the morning or evening of stimulation day 5, or morning of stimulation day 6; continue until hCG is administered.

There are no dosage adjustments provided in the manufacturer's labeling (has not been studied).

Concerns related to adverse effects:

• Hypersensitivity: Hypersensitivity reactions, including severe anaphylactoid reactions, have been reported after initial dose and months after starting therapy; use with caution in patients with signs and symptoms of active allergic conditions or known history of allergic predisposition. Treatment is not recommended in patients with severe allergic conditions.

Other warnings/precautions:

• Experienced specialists: Should only be prescribed by fertility specialists.