Caffeine

Caffeine citrate is a central nervous system stimulant.

Caffeine citrate is used to treat breathing problems in premature infants.

Caffeine citrate may also be used for purposes not listed in this medication guide.

Caffeine citrate should not be given to a child who has ever had an allergic reaction to this medicine.

Caffeine citrate should not be given to a child who has ever had an allergic reaction to this medicine.

To make sure caffeine citrate is safe for your child, tell your doctor if the child has:

• seizures;
• heart disease; or
• liver or kidney disease.

Caffeine may be found in some form under the following brand names:

• Alagesic

• Alert brand of caffeine

• Alka-Seltzer Morning Relief

• Americet

• Anacin

• Anacin Advanced Headache Formula

• Anolor 300

• Anoquan

• Arcet

• Arthriten

• Arthriten Inflammatory Pain

• Ascomp with Codeine

• Aspircaf

• Backaid IPF

• Backprin

• Bayer Back and Body Pain

• Bayer Headache Relief

• Bayer Migraine

• Bayer Select

• Bc

• BC Arthritis

• Cafcit

• Cafergot

• Caffedrine

• Cafgesic

• Capacet

• Combiflex

• Cope brand of aspirin-caffeine

• Cp-2

• Diurex

• Diurex Water Caps

• Dolgic LQ

• Dolgic Plus

• Dolmar

• Durabac

• Durabac Forte

• Emagrin

• Emagrin Forte

• Endolor

• Esgic

• Ex-Pain

• Exaprin

• Excedrin

• Excedrin Aspirin Free

• Excedrin Quick Tab

• Excedrin Tension Headache

• Ezol

• Femcet

• Fioricet

• Fioricet with Codeine

• Fiorinal

• Fiorinal with Codeine

• Fiormor

• Fiorpap

• Fiortal

• Fiortal with Codeine

• Flextra Plus

• Fortabs

• G-1

• Genace

• Genasan

• Geone

• Goody's Headache Relief Shot

• Goody's Migraine Relief

• Goodys Extra Strength

• Hycomine Compound

• Ide-cet

• Idenal

• Isocet

• Isollyl

• Keep Alert

• Laniroif

• Levacet

• Lucidex

• Major-Cin

• Margesic

• Medigesic

• Midol Maximum Strength Menstrual

• Migergot

• MigraTen

• Minotal

• Mygracet

• No Doz

• Nonbac

• Norgesic

• Orbivan

• Orphengesic

• P-A-C Analgesic

• Pacaps

• Painaid ESF

• Pamprin Max Formula

• Pancold S

• Panlor DC

• Panlor SS

• Pc-cap

• Pep-Back

• Pharmagesic

• Phrenilin with Caffeine and Codeine

• Prodrin

• Propoxyphene Compound 65

• Q-Acin

• Repan

• Revive

• Rid-A-Pain

• Rx-Act Headache Formula

• Saleto

• Saleto-D

• Scot Tussin Original

• Sedalmex

• Sinapils

• Stanback Headache Powder

• Stanback Headache Powder Reformulated Jan 2011

• Stat Awake

• Stay Alert

• Supac

• Synalgos-DC

• Tenake

• Tencet

• Trezix

• Trezix Reformulated Oct 2011

• Triad

• Tussirex

• Two-Dyne

• Uni-Ann

• Uni-Case

• Valorin Extra

• Vanquish

• Verv

• Vivarin

• Wakespan

• Waykup

• Wigraine

• Zebutal

• Zerlor

Caffeine tablets are used as an alertness aid to help you keep awake when you experience drowsiness or unusual tiredness or weakness. Do not use caffeine as substitute for sleep.

Caffeine oral solution is used to treat short-term apnea of prematurity when premature babies (infants between 28 and 32 weeks gestational age) stop breathing. Apnea of prematurity is caused by the baby's breathing centers not being fully developed.

caffeine is available with or without your doctor's prescription.

• Central Nervous System Stimulant
• Phosphodiesterase Enzyme Inhibitor, Nonselective

Hypersensitivity to caffeine or any component of the formulation; sodium benzoate is not for use in neonates

There are no dosage adjustments provided in the manufacturer's labeling. Use with caution.

Adverse events were observed in animal reproduction studies. Caffeine crosses the placenta; serum concentrations in the fetus are similar to those in the mother (Grosso 2005). Based on current studies, usual dietary exposure to caffeine is unlikely to cause congenital malformations (Brent 2011). However, available data shows conflicting results related to maternal caffeine use and the risk of other adverse events, such as spontaneous abortion or growth retardation (Brent 2011; Jahanfar 2013). The half-life of caffeine is prolonged during the second and third trimesters of pregnancy and maternal and fetal exposure is also influenced by maternal smoking or drinking (Brent 2011; Koren 2000). Current guidelines recommend limiting caffeine intake from all sources to ≤200 mg/day (ACOG 2010).

• If you have any questions about caffeine, please talk with your health care provider.
• If your symptoms do not improve or if they become worse, check with your health care provider.
• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. Consult with your health care provider for additional questions or concerns about the use of caffeine.

Caffeine Citrate:
28 Weeks to Less Than 33 Weeks Gestational Age:
-Loading Dose: 20 mg/kg IV over 30 minutes one time.
-Maintenance Dose: 5 mg/kg orally or IV over 10 minutes every 24 hours.
-Treatment Duration: Safety and efficacy of this drug for treatment of apnea of prematurity have not been established beyond 12 days.

Use: Short-term treatment of apnea of prematurity in infants.

Caffeine Citrate: Use with caution in infants with impaired renal function; monitor serum drug concentrations and adjust dose accordingly to avoid toxicity.

Caffeine Citrate: Use with caution in infants with impaired hepatic function; monitor serum drug concentrations and adjust dose accordingly to avoid toxicity.