Baytril Injection

Name: Baytril Injection

Baytril® 100 (enrofloxacin)

100 mg/mL Antimicrobial
Injectable Solution

For Subcutaneous Use in Beef Cattle, Non-Lactating Dairy Cattle and Swine Only
Not For Use In Female Dairy Cattle 20 Months of Age or Older
Or In Calves To Be Processed For Veal

CAUTION:
Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.
Federal (U.S.A.) law prohibits the extra-label use of this drug in food-producing animals.

Dosage and administration

Baytril® 100 provides flexible dosages and durations of therapy.

Baytril® 100 may be administered as a single dose for one day (cattle and swine) or for multiple days (cattle) of therapy.

Selection of the appropriate dose and duration of therapy should be based on an assessment of the severity of disease, pathogen susceptibility and clinical response.

Cattle:

Single-Dose Therapy: Administer once, a subcutaneous dose of 7.5 - 12.5 mg/kg of body weight (3.4 - 5.7 mL/100 lb).

Multiple-DayTherapy: Administer daily, a subcutaneous dose of 2.5 - 5.0 mg/kg of body weight (1.1 - 2.3 mL/100 lb). Treatment should be repeated at 24-hour intervals for three days. Additional treatments may be given on Days 4 and 5 to animals that have shown clinical improvement but not total recovery.

Administered dose volume should not exceed 20 mL per injection site.

Table 1 – Baytril® 100 Dose and Treatment Schedule for Cattle**
* *Dose volumes have been rounded to the nearest 0.5 mL within the dose range.
Weight
(lb)		 Single-Dose Therapy
7.5 - 12.5 mg/kg
Dose Volume (mL)		 Multiple-Day Therapy
2.5 - 5.0 mg/kg
Dose Volume (mL)
100 3.5 - 5.5 1.5 - 2.0
200 7.0 - 11.0 2.5 - 4.5
300 10.5 - 17.0 3.5 - 6.5
400 14.0 - 22.5 4.5 - 9.0
500 17.0 - 28.5 5.5 - 11.5
600 20.5 - 34.0 7.0 - 13.5
700 24.0 - 39.5 8.0 - 16.0
800 27.5 - 45.5 9.0 - 18.0
900 31.0 - 51.0 10.0 - 20.5
1000 34.0 - 57.0 11.0 - 23.0
1100 37.5 - 62.5 12.5 - 25.0

Swine:

Administer once, behind the ear, a subcutaneous dose of 7.5 mg/kg of body weight (3.4 mL/100 lb).

Administered dose volume should not exceed 5 mL per injection site.

Table 2 – Baytril®100 Dose and Treatment Schedule for Swine
WEIGHT
(lb)		 Dose
Volume
(mL)
50 1.7
100 3.4
150 5.1
200 6.8
250 8.5

Microbiology

Enrofloxacin is bactericidal and exerts its antibacterial effect by inhibiting bacterial DNA gyrase (a type II topoisomerase) thereby preventing DNA supercoiling and replication which leads to cell death.1 Enrofloxacin is active against Gram-negative and Gram-positive bacteria.

Toxicology

The oral LD50 for laboratory rats was greater than 5000 mg/kg of body weight. Ninety-day feeding studies in dogs and rats revealed no observable adverse effects at treatment rates of 3 and 40 mg/kg respectively. Chronic studies in rats and mice revealed no observable adverse effects at 5.3 and 323 mg/kg respectively. There was no evidence of carcinogenic effect in laboratory animal models. A two-generation rat reproduction study revealed no effect with 10 mg/kg treatments. No teratogenic effects were observed in rabbits at doses of 25 mg/kg or in rats at 50 mg/kg.

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