Arestin eent

Periodontitis

Reduction of pocket depth in the treatment of adult periodontitis; used as an adjunct to scaling and root planing procedures.1

Contraindications

• Known hypersensitivity to minocycline or other tetracyclines.1

Warnings/Precautions

Warnings

Avoid use during tooth development (e.g., the last half of pregnancy, infancy, childhood to the age of 8 years); potential for permanent tooth discoloration (yellow-gray brown) or enamel hypoplasia.1

Sensitivity Reactions

Possible photosensitivity reactions (e.g., exaggerated sunburn reaction).1 Discontinue therapy at the first sign of skin erythema.1

General Precautions

Use in acutely abscessed periodontal pockets has not been studied and is not recommended.1

Not studied for use in the regeneration of alveolar bone, either in preparation for or in conjunction with placement of endosseous (dental) implants or in the treatment of failing implants.1

Possible overgrowth of nonsusceptible organisms, including fungi.1 Use with caution in patients with a history of or predisposition to oral candidiasis.1 Safety and efficacy not established in patients with concomitant oral candidiasis.1

Not studied in immunocompromised patients (e.g., those with diabetes or HIV infection, those receiving chemotherapy or radiation therapy).1

Specific Populations

Category D.1

Distributed into milk.1 Discontinue nursing or the drug.1

Safety and efficacy not established in children <18 years of age.1 2 Possible permanent tooth discoloration (see Dental Effects in Cautions).1

Common Adverse Effects

Periodontitis,1 tooth disorder,1 tooth caries,1 dental pain,1 gingivitis,1 headache,1 infection,1 stomatitis,1 mouth ulceration,1 flu syndrome,1 pharyngitis,1 pain,1 dyspepsia,1 dental infection,1 mucous membrane disorder.1

Minocycline is a tetracycline antibiotic that fights bacteria in the body.

Minocycline is used to treat many different bacterial infections, such as urinary tract infections, respiratory infections, skin infections, severe acne, gonorrhea, tick fever, chlamydia, and others.

Minocycline may also be used for purposes not listed in this medication guide.

Take minocycline exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take this medicine with a full glass of water.

You may take minocycline with or without food.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Minocycline will not treat a viral infection such as the flu or a common cold.

If you use this medicine long-term, you may need frequent medical tests.

This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using minocycline.

Store at room temperature away from moisture, heat, and light.

Throw away any minocycline not used before the expiration date on the medicine label. Using expired minocycline can cause damage to your kidneys.

Applies to minocycline: oral capsule, oral capsule extended release, oral suspension, oral tablet, oral tablet extended release

Other dosage forms:

• intravenous powder for solution

Along with its needed effects, minocycline may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking minocycline:

• Black, tarry stools
• blistering, peeling, or loosening of the skin
• blood in the urine or stools
• blurred or double vision
• bulging soft spot on the head of an infant
• chest pain, possibly moving to the left arm, neck, or shoulder
• confusion
• diarrhea
• dizziness or lightheadedness
• eye pain
• fast heartbeat
• general feeling of discomfort or illness
• general tiredness and weakness
• hives, itching, or skin rash
• joint or muscle pain
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• loss of appetite
• nausea or vomiting
• red skin lesions, often with a purple center
• severe headache
• severe stomach pain
• sores, ulcers, or white spots on the lips or in the mouth
• troubled breathing
• unusual bleeding or bruising
• upper right abdominal or stomach pain
• yellow eyes and skin

Some side effects of minocycline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Continuing ringing or buzzing or other unexplained noise in the ears
• difficulty with moving
• hearing loss
• hives or welts
• muscle stiffness
• redness of the skin
• sleepiness or unusual drowsiness

• Bloating
• discoloration of the tooth
• increased sensitivity of the skin to sunlight
• indigestion
• severe sunburn

200 mg IV initially followed by 100 mg IV every 12 hours
Maximum dose: 400 mg/24 hours

Use: When penicillin is contraindicated, as an alternative agent for the treatment of meningitis due to Neisseria meningitidis

100 mg orally every 12 hours for 5 days

Comments:
-Diagnostic laboratory studies (including serotyping and susceptibility testing) are recommended to establish the carrier state and the appropriate therapy.
-Prophylactic use of this drug is only recommended when risk of meningococcal meningitis is high.

Use: In the treatment of asymptomatic carriers of N meningitidis to eliminate meningococci from the nasopharynx

IV: 200 mg IV initially followed by 100 mg IV every 12 hours
Maximum dose: 400 mg/24 hours

Oral:
Infection due to Staphylococcus aureus: 200 mg orally initially followed by 100 mg orally every 12 hours
-Alternative regimen (if more frequent dosing preferred): 100 to 200 mg orally initially followed by 50 mg orally 4 times a day

Infection due to Mycobacterium marinum: 100 mg orally every 12 hours for 6 to 8 weeks

Comments:
-Not the drug of choice for any type of staphylococcal infection
-The optimal dose has not been established to treat M marinum infections; the recommended dose has been successful in limited cases.

Uses: For the treatment of skin and skin structure infections due to S aureus when bacteriologic testing shows suitable susceptibility to this drug; for the treatment of infections due to M marinum

Infectious Diseases Society of America (IDSA) Recommendations: 100 mg orally twice a day

Comments:
-Recommended for skin and soft tissue infections due to methicillin-susceptible and methicillin-resistant S aureus
-After an initial dose of 200 mg, recommended for purulent cellulitis (cellulitis associated with purulent drainage/exudate without a drainable abscess) due to methicillin-resistant S aureus
-Current guidelines should be consulted for additional information.

Urethritis in men: 100 mg orally every 12 hours for 5 days
Infections other than urethritis and anorectal infections in men: 200 mg orally initially followed by 100 mg orally every 12 hours for at least 4 days

Comments:
-For infections other than urethritis and anorectal infections in men, posttherapy cultures are recommended within 2 to 3 days.

Uses: When penicillin is contraindicated, as an alternative agent for the treatment of the following infections: Uncomplicated urethritis in men due to N gonorrhoeae and other gonococcal infections; infection in women due to N gonorrhoeae

Data not available

Comments:
-This drug is not significantly removed by hemodialysis or peritoneal dialysis.