Allegra-D (as a combination product containing Fexofenadine, Pseudoephedrine)

The combination of fexofenadine and pseudoephedrine comes as an extended-release (long-acting) tablet to take by mouth. The fexofenadine and pseudoephedrine 12-hour tablet is usually taken once or twice a day on an empty stomach with water. The fexofenadine and pseudoephedrine 24-hour tablet is usually taken once a day on an empty stomach with water. Fexofenadine and pseudoephedrine will work better if it is not taken with fruit juices such as orange, grapefruit, or apple juice. Take fexofenadine and pseudoephedrine at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take fexofenadine and pseudoephedrine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Fexofenadine and pseudoephedrine controls the symptoms of seasonal allergic rhinitis but does not cure this condition. Continue to take fexofenadine and pseudoephedrine even if you feel well and are not experiencing these symptoms. If you wait too long between doses, your symptoms may become worse.

Swallow the tablets whole; do not split, chew, or crush them.

Caffeine-containing beverages (coffee, tea, sodas, and energy drinks) may increase the restlessness and insomnia caused by pseudoephedrine in sensitive individuals, so you may wish to drink less of these beverages. Talk to your doctor about drinking these beverages while taking this medication.

Fexofenadine and pseudoephedrine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• headache
• nausea
• stomach pain
• heartburn
• dry mouth
• throat irritation
• back pain
• pale skin

Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:

• nervousness
• dizziness
• difficulty falling asleep or staying asleep
• weakness
• fear, anxiety, or tenseness
• hallucinating (seeing things or hearing voices that do not exist)
• shaking of a part of your body that you cannot control
• seizure
• fainting
• blurred vision
• hives
• rash
• itching
• difficulty breathing or swallowing
• swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
• hoarseness
• fast pounding, or irregular heartbeat
• difficulty or pain when urinating

Fexofenadine and pseudoephedrine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).