Aliskiren (Oral Route)

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Grapefruit Juice

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Airway surgery, history of—At risk for severe complications from angioedema (swelling of the face, lips, tongue, throat, arms, or legs).

• Angioedema, history of—May increase the risk of this condition occurring again.

• Congestive heart failure, severe
• Heart attack, history—Use may lead to kidney problems.

• Diabetes or
• Kidney problems—May increase risk of having high potassium in the blood.

• Diabetes patients who are also taking certain blood pressure medicines such as angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs)—Should not be used in patients with this condition.

• Electrolyte imbalances (e.g., high potassium or low sodium in the body) or
• Fluid imbalances (caused by dehydration, vomiting, or diarrhea)—Use with caution. May make these conditions worse.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep the tablets in its original container in a dry place.