Adlyxin lixisenatide

Name: Adlyxin lixisenatide

What is lixisenatide, and how does it work?

  • Lixisenatide is an injectable drug that reduces the level of sugar (glucose) in the blood. It is used for the treatment type 2 diabetes and is similar to
    • exenatide (Byetta),
    • liraglutide (Victoza),
    • dulaglutide (Trulicity), and
    • abliglutide (Tanzeum).
  • Lixisenatide belongs in a class of drugs called incretin mimetics because these drugs mimic the effects of incretins. Incretins, such as human-glucagon-like peptide-1 (GLP-1), are hormones that are produced and released into the blood by the intestine in response to food. GLP-1 increases the secretion of insulin from the pancreas, slows absorption of glucose from the gut, and reduces the action of glucagon. (Glucagon is a hormone that increases glucose production by the liver.) All three of these actions reduce levels of glucose in the blood. In addition, GLP-1 reduces appetite. Lixisenatide is a synthetic (man-made) hormone that resembles and acts like GLP-1. In studies, lixisenatide treated patients achieved lower blood glucose levels and experienced weight loss.

What brand names are available for lixisenatide?

  • Adlyxin is the brand name available for lixisenatide available in the US.

Is lixisenatide available as a generic drug?

  • No

What are the uses for lixisenatide?

  • Adlyxin is used with diet and exercise to improve control of blood sugar in adults with type 2 diabetes.
  • It should not be used for the treatment of diabetic ketoacidosis or type 1 diabetes.

What is the dosage for lixisenatide?

  • The recommended starting dose of Adlyxin is 10 mcg injected under the skins (subcutaneously) once daily for 14 days.
  • The dose should be increased on day 15 to the maintenance dose of 20 mcg once daily.
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