Pediatex 12

Carbinoxamine is a prescription medication used to treat runny nose, stuffy nose, watery eyes, and itching caused by hay fever, seasonal and perennial allergies, and other allergic conditions. Carbinoxamine belongs to a group of drugs called antihistamines, which work by stopping the action of histamines, a substance produced in the body to react to foreign substances.

This medication comes in an extended-release oral suspension (liquid) form to be taken by mouth, once every 12 hours. It may be taken with or without food.

Common side effects of carbinoxamine include sleepiness, dizziness, loss of coordination, stomach irritation, and thickening of mucus. Do not drive or operate heavy machinery until you know how carbinoxamine affects you.

Pediatex 12 is part of the drug class:

• Aminoalkyl ethers

Serious side effects have been reported with carbinoxamine. See “Drug Precautions” section.

Common side effects of carbinoxamine include:

• sleepiness
• dizziness
• loss of coordination
• stomach irritation
• thickening of mucus.

Alcohol may intensify some of the side effects of this medication.

This is not a complete list of carbinoxamine side effects. Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

• alcohol
• barbiturates such as thiopental (Pentothal), butalbital (Fioricet, Fiorinal), phenobarbital (Luminal)
• benzodiazepines such as diazepam (Valium), alprazolam (Xanax), and lorazepam (Ativan)
• buspirone (Buspar)
• non-benzodiazepines such as zolpidem (Ambien), eszopiclone (Lunesta), and zaleplon (Sonata)
• CNS depressants such as carisoprodol (Soma) and cyclobenzoprine (Flexeril)
• monoamine oxidase inhibitors (MAOIs) such as phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl, Emsam), and amitriptyline (Elavil)

This is not a complete list of carbinoxamine drug interactions. Ask your doctor or pharmacist for more information.

Serious side effects have been reported with carbinoxamine including:

• Pediatric Mortality: Deaths have been reported in children less than 2 years of age who were taking carbinoxamine-containing drug products; therefore, carbinoxamine is not used in children younger than 2 years of age.
• Concomitant Medical Conditions: Carbinoxamine should be used with caution in patients with:
  • increased intraocular pressure
  • glaucoma
  • hyperthyroidism
  • cardiovascular disease
  • hypertension
  • stenosing (narrowing) peptic ulcer
  • enlargement of the prostate gland
  • bladder neck obstruction, or pyloroduodenal obstruction
• Allergic Reactions due to Sulfites: Carbinoxamine contains a sulfite that may cause allergic-type reactions, including anaphylaxis, life-threatening, or less severe asthmatic episodes in those with an allergy to sulfites/sulfa-containing drugs.

Carbinoxamine can cause drowsiness. Do not drive or operate heavy machinery until you know how carbinoxamine affects you.

Do not give carbinoxamine to the following patients:

• children younger than 2 years of age because deaths have been reported in this age group
• nursing mothers because of the risk of mortality in infants given carbinoxamine-containing products
• patients who are hypersensitive to carbinoxamine maleate or any of the inactive ingredients in carbinoxamine
• who are taking monoamine oxidase inhibitors (MAOI)

Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of carbinoxamine, there are no specific foods that you must exclude from your diet when receiving carbinoxamine.

Alcohol may intensify some of the side effects of this medication.

Tell your doctor if you are breastfeeding or plan to breastfeed.

Because of the risk of death in infants given carbinoxamine-containing drugs, use of carbinoxamine is contraindicated in nursing mothers.

Store carbinoxamine ER suspension at room temperature.

Dispense in tight, light-resistant container with child-resistant closure.

Keep this and all medicines out of the reach of children.

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Very young children are usually more sensitive to the effects of this medicine. Before giving any of these combination medicines to a child, check the package label very carefully. Some of these medicines are too strong for use in children. If you are not certain whether a specific product can be given to a child, or if you have any questions about the amount to give, check with your health care professional, especially if it contains:

• Antihistamines—Nightmares, unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in children taking antihistamines.
• Decongestants (e.g., ephedrine, phenylephrine, pseudoephedrine—Increases in blood pressure may be more likely to occur in children taking decongestants.
• Iodides (e.g., calcium iodide and iodinated glycerol)—These medicines pass into the breast milk and may cause unwanted effects, such as underactive thyroid, in the baby.
• Narcotic antitussives (e.g., codeine, dihydrocodeine, hydrocodone, and hydromorphone)—Breathing problems may be especially likely to occur in children younger than 2 years of age taking narcotic antitussives. Also, unusual excitement or restlessness may be more likely to occur in children receiving these medicines.
• Salicylates (e.g., aspirin)—Do not give medicines containing aspirin or other salicylates to a child or teenager with a fever or other symptoms of a virus infection, especially flu or chickenpox, without first discussing its use with your child's doctor. This is very important because salicylates may cause a serious illness called Reye's syndrome in children with fever caused by a virus infection, especially flu or chickenpox. Also, children may be more sensitive to the aspirin or other salicylates contained in some of these medicines, especially if they have a fever or have lost large amounts of body fluid because of vomiting, diarrhea, or sweating.

Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .

Geriatric

The elderly are usually more sensitive to the effects of this medicine, especially if it contains:

• Antihistamines—Confusion, difficult or painful urination, dizziness, drowsiness, feeling faint, or dryness of mouth, nose, or throat may be more likely to occur in elderly patients. Also, nightmares or unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in the elderly taking antihistamines.
• Decongestants (e.g., ephedrine, phenylephrine, pseudoephedrine—Confusion, hallucinations, drowsiness, or convulsions (seizures) may be more likely to occur in the elderly, who are usually more sensitive to the effects of this medicine. Also, increases in blood pressure may be more likely to occur in elderly persons taking decongestants.

Pregnancy

The occasional use of a cough/cold combination is not likely to cause problems in the fetus or in the newborn baby. However, when these medicines are used at higher doses and/or for a long time, the chance that problems might occur may increase. For the individual ingredients of these combinations, the following information should be considered before you decide to use a particular cough/cold combination:

• Acetaminophen—Studies on birth defects have not been done in humans. However, acetaminophen has not been shown to cause birth defects or other problems in humans.
• Alcohol—Some of these combination medicines contain a large amount of alcohol. Too much use of alcohol during pregnancy may cause birth defects.
• Antihistamines—Antihistamines have not been shown to cause problems in humans.
• Caffeine—Studies in humans have not shown that caffeine causes birth defects. However, studies in animals have shown that caffeine causes birth defects when given in very large doses (amounts equal to the amount of caffeine contained in 12 to 24 cups of coffee a day).
• Codeine—Although studies on birth defects with codeine have not been done in humans, it has not been reported to cause birth defects in humans. Codeine has not been shown to cause birth defects in animal studies, but it caused other unwanted effects. Also, regular use of narcotics during pregnancy may cause the baby to become dependent on the medicine. This may lead to withdrawal side effects after birth. In addition, narcotics may cause breathing problems in the newborn baby if taken by the mother just before delivery.
• Hydrocodone—Although studies on birth defects with hydrocodone have not been done in humans, it has not been reported to cause birth defects in humans. However, hydrocodone has been shown to cause birth defects in animals when given in very large doses. Also, regular use of narcotics during pregnancy may cause the baby to become dependent on the medicine. This may lead to withdrawal side effects after birth. In addition, narcotics may cause breathing problems in the newborn baby if taken by the mother just before delivery.
• Iodides (e.g., calcium iodide and iodinated glycerol)—Not recommended during pregnancy. Iodides have caused enlargement of the thyroid gland in the fetus and resulted in breathing problems in newborn babies whose mothers took iodides in large doses for a long period of time.
• Phenylephrine—Studies on birth defects with phenylephrine have not been done in either humans or animals.
• Pseudoephedrine—Studies on birth defects with pseudoephedrine have not been done in humans. In animal studies pseudoephedrine did not cause birth defects but did cause a decrease in average weight, length, and rate of bone formation in the animal fetus when given in high doses.
• Salicylates (e.g., aspirin)—Studies on birth defects in humans have been done with aspirin, but not with salicylamide or sodium salicylate. Salicylates have not been shown to cause birth defects in humans. However, salicylates have been shown to cause birth defects in animals.

Some reports have suggested that too much use of aspirin late in pregnancy may cause a decrease in the newborn's weight and possible death of the fetus or newborn infant. However, the mothers in these reports had been taking much larger amounts of aspirin than are usually recommended. Studies of mothers taking aspirin in the doses that are usually recommended did not show these unwanted effects. However, there is a chance that regular use of salicylates late in pregnancy may cause unwanted effects on the heart or blood flow in the fetus or newborn baby.

Use of salicylates, especially aspirin, during the last 2 weeks of pregnancy may cause bleeding problems in the fetus before or during delivery, or in the newborn baby. Also, too much use of salicylates during the last 3 months of pregnancy may increase the length of pregnancy, prolong labor, cause other problems during delivery, or cause severe bleeding in the mother before, during, or after delivery. Do not take aspirin during the last 3 months of pregnancy unless it has been ordered by your doctor.

Breast Feeding

If you are breastfeeding, the chance that problems might occur depends on the ingredients of the combination. For the individual ingredients of these combinations, the following apply:

• Acetaminophen—Acetaminophen passes into the breast milk. However, it has not been reported to cause problems in nursing babies.
• Alcohol—Alcohol passes into the breast milk. However, the amount of alcohol in recommended doses of this medicine does not usually cause problems in nursing babies.
• Antihistamines—Small amounts of antihistamines pass into the breast milk. Antihistamine-containing medicine is not recommended for use while breastfeeding since most antihistamines are especially likely to cause side effects, such as unusual excitement or irritability, in the baby. Also, since antihistamines tend to decrease the secretions of the body, the flow of breast milk may be reduced in some patients.
• Caffeine—Small amounts of caffeine pass into the breast milk and may build up in the nursing baby. However, the amount of caffeine in recommended doses of this medicine does not usually cause problems in nursing babies.
• Codeine and other narcotic cough medicines (e.g., dihydrocodeine, hydrocodone, and hydromorphone)—Codeine is changed to morphine in the body. Some people change codeine to morphine more quickly than others. These individuals are called "ultra-rapid metabolizers of codeine". If a nursing mother is an ultra-rapid metabolizer of codeine, it could lead to a morphine overdose in the nursing baby and cause very serious side effects. A nursing mother should talk to her doctor if she has any questions about taking codeine or about how this medicine may affect her baby .
• Decongestants (e.g., ephedrine, phenylephrine, pseudoephedrine—Phenylephrine has not been reported to cause problems in nursing babies. Ephedrine and pseudoephedrine pass into the breast milk and may cause unwanted effects in nursing babies (especially newborn and premature babies).
• Iodides (e.g., calcium iodide and iodinated glycerol)—These medicines pass into the breast milk and may cause unwanted effects, such as underactive thyroid, in the baby.
• Salicylates (e.g., aspirin)—Salicylates pass into the breast milk. Although salicylates have not been reported to cause problems in nursing babies, it is possible that problems may occur if large amounts are taken regularly.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

• Alfuzosin
• Amifampridine
• Amiodarone
• Amisulpride
• Amitriptyline
• Amprenavir
• Anagrelide
• Apomorphine
• Aripiprazole
• Aripiprazole Lauroxil
• Arsenic Trioxide
• Artemether
• Asenapine
• Astemizole
• Atazanavir
• Azithromycin
• Bedaquiline
• Bepridil
• Boceprevir
• Buserelin
• Chloroquine
• Chlorpromazine
• Ciprofloxacin
• Cisapride
• Citalopram
• Clarithromycin
• Clomipramine
• Clorgyline
• Clozapine
• Cobicistat
• Crizotinib
• Cyclobenzaprine
• Cyclopropane
• Dabrafenib
• Darunavir
• Dasabuvir
• Defibrotide
• Degarelix
• Delamanid
• Delavirdine
• Desipramine
• Deslorelin
• Deutetrabenazine
• Dichlorphenamide
• Dihydroergotamine
• Disopyramide
• Dofetilide
• Dolasetron
• Domperidone
• Donepezil
• Doxepin
• Dronedarone
• Droperidol
• Ebastine
• Efavirenz
• Elvitegravir
• Eribulin
• Erythromycin
• Escitalopram
• Famotidine
• Felbamate
• Fingolimod
• Flecainide
• Fluconazole
• Fluoxetine
• Fluvoxamine
• Formoterol
• Foscarnet
• Fosphenytoin
• Furazolidone
• Galantamine
• Gatifloxacin
• Gemifloxacin
• Gonadorelin
• Goserelin
• Granisetron
• Halofantrine
• Haloperidol
• Halothane
• Histrelin
• Hydroquinidine
• Hydroxychloroquine
• Hydroxyzine
• Ibutilide
• Iloperidone
• Imipramine
• Indinavir
• Influenza Virus Vaccine, Live
• Iproniazid
• Isocarboxazid
• Itraconazole
• Ivabradine
• Ketoconazole
• Ketorolac
• Lapatinib
• Leuprolide
• Levofloxacin
• Levomethadyl
• Linezolid
• Lumefantrine
• Mefloquine
• Mesoridazine
• Methadone
• Methotrimeprazine
• Methylene Blue
• Metronidazole
• Mifepristone
• Mizolastine
• Moclobemide
• Moricizine
• Moxifloxacin
• Nafarelin
• Nalmefene
• Naltrexone
• Nefazodone
• Nelfinavir
• Nialamide
• Nilotinib
• Norfloxacin
• Octreotide
• Ofloxacin
• Olanzapine
• Ombitasvir
• Ondansetron
• Paliperidone
• Panobinostat
• Papaverine
• Pargyline
• Paritaprevir
• Paroxetine
• Pasireotide
• Pazopanib
• Pentamidine
• Perphenazine
• Phenelzine
• Pimavanserin
• Pimozide
• Pipamperone
• Piperaquine
• Pitolisant
• Posaconazole
• Potassium
• Probucol
• Procainamide
• Procarbazine
• Prochlorperazine
• Promethazine
• Propafenone
• Protriptyline
• Quetiapine
• Quinidine
• Quinine
• Ranolazine
• Rasagiline
• Ribociclib
• Rilpivirine
• Riociguat
• Risperidone
• Ritonavir
• Safinamide
• Saquinavir
• Selegiline
• Sertindole
• Sevoflurane
• Sibutramine
• Sodium Oxybate
• Sodium Phosphate
• Sodium Phosphate, Dibasic
• Sodium Phosphate, Monobasic
• Solifenacin
• Sorafenib
• Sotalol
• Sparfloxacin
• Sulpiride
• Sultopride
• Sunitinib
• Tacrolimus
• Tamoxifen
• Telaprevir
• Telavancin
• Telithromycin
• Tetrabenazine
• Thioridazine
• Tipranavir
• Tizanidine
• Toloxatone
• Tolterodine
• Toremifene
• Tranylcypromine
• Trazodone
• Trimipramine
• Triptorelin
• Vandetanib
• Vardenafil
• Vemurafenib
• Venlafaxine
• Vilanterol
• Vinflunine
• Voriconazole
• Vorinostat
• Ziprasidone
• Zolmitriptan
• Zotepine
• Zuclopenthixol

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abciximab
• Acarbose
• Aceclofenac
• Acemetacin
• Acenocoumarol
• Acepromazine
• Acetyldigoxin
• Adenosine
• Alefacept
• Alfentanil
• Alipogene Tiparvovec
• Almotriptan
• Alprazolam
• Alteplase, Recombinant
• Amiloride
• Amineptine
• Amiodarone
• Amisulpride
• Amitriptyline
• Amitriptylinoxide
• Amobarbital
• Amoxapine
• Amphetamine
• Amtolmetin Guacil
• Amygdalin
• Anagrelide
• Ancrod
• Anileridine
• Anisindione
• Antithrombin III Human
• Apixaban
• Aprepitant
• Aprobarbital
• Ardeparin
• Argatroban
• Aripiprazole
• Arsenic Trioxide
• Asenapine
• Aspirin
• Atazanavir
• Axitinib
• Baclofen
• Balsalazide
• Bemiparin
• Bendroflumethiazide
• Benperidol
• Benzphetamine
• Benzthiazide
• Betamethasone
• Betrixaban
• Bismuth Subsalicylate
• Bivalirudin
• Blinatumomab
• Boceprevir
• Bosutinib
• Bromazepam
• Bromfenac
• Bromocriptine
• Bromopride
• Brompheniramine
• Bucindolol
• Budesonide
• Bufexamac
• Bumetanide
• Buprenorphine
• Bupropion
• Buspirone
• Butabarbital
• Butalbital
• Butorphanol
• Calcifediol
• Cangrelor
• Carbamazepine
• Carbinoxamine
• Carisoprodol
• Carmustine
• Carphenazine
• Carteolol
• Carvedilol
• Celecoxib
• Ceritinib
• Certoparin
• Chloral Hydrate
• Chlordiazepoxide
• Chlorothiazide
• Chlorpheniramine
• Chlorpromazine
• Chlorpropamide
• Chlorthalidone
• Chlorzoxazone
• Choline Magnesium Trisalicylate
• Choline Salicylate
• Cilostazol
• Cimetidine
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clobazam
• Clomipramine
• Clonazepam
• Clonixin
• Clopamide
• Clopidogrel
• Clorazepate
• Clorgyline
• Clozapine
• Cobimetinib
• Cocaine
• Codeine
• Conivaptan
• Cortisone
• Cyclobenzaprine
• Cyclopenthiazide
• Cyclosporine
• Dabigatran Etexilate
• Daclatasvir
• Dalteparin
• Danaparoid
• Dantrolene
• Darunavir
• Dasabuvir
• Deferasirox
• Deferoxamine
• Defibrotide
• Deflazacort
• Delavirdine
• Dermatan Sulfate
• Desipramine
• Desirudin
• Deslanoside
• Desmopressin
• Desogestrel
• Desvenlafaxine
• Dexamethasone
• Dexibuprofen
• Dexketoprofen
• Dexmedetomidine
• Dextroamphetamine
• Dextromethorphan
• Dezocine
• Diacetylmorphine
• Diazepam
• Diazoxide
• Dibenzepin
• Dichloralphenazone
• Diclofenac
• Dicumarol
• Dienogest
• Difenoxin
• Diflunisal
• Digitalis
• Digitoxin
• Digoxin
• Dihydroartemisinin
• Dihydrocodeine
• Dilevalol
• Diltiazem
• Diphenhydramine
• Diphenoxylate
• Dipyridamole
• Dipyrone
• Dolasetron
• Domperidone
• Donepezil
• Dothiepin
• Doxepin
• Doxorubicin
• Doxorubicin Hydrochloride Liposome
• Doxylamine
• Dronedarone
• Droperidol
• Drospirenone
• Droxicam
• Duloxetine
• Edoxaban
• Elbasvir
• Eletriptan
• Eliglustat
• Enflurane
• Enoxacin
• Enoxaparin
• Entacapone
• Eplerenone
• Epoprostenol
• Eptifibatide
• Ergonovine
• Erlotinib
• Erythromycin
• Escitalopram
• Eslicarbazepine Acetate
• Estazolam
• Estradiol Cypionate
• Estradiol Valerate
• Eszopiclone
• Ethacrynic Acid
• Ethchlorvynol
• Ethinyl Estradiol
• Ethopropazine
• Ethylmorphine
• Ethynodiol Diacetate
• Etintidine
• Etodolac
• Etofenamate
• Etonogestrel
• Etoricoxib
• Etravirine
• Felbinac
• Fenoprofen
• Fentanyl
• Fepradinol
• Feprazone
• Feverfew
• Flibanserin
• Floctafenine
• Fluconazole
• Flufenamic Acid
• Flunitrazepam
• Fluocortolone
• Fluoxetine
• Fluphenazine
• Flurazepam
• Flurbiprofen
• Fluspirilene
• Fluvoxamine
• Fondaparinux
• Fosaprepitant
• Fosphenytoin
• Fospropofol
• Frovatriptan
• Furazolidone
• Furosemide
• Ginkgo
• Glimepiride
• Glipizide
• Glyburide
• Golimumab
• Gossypol
• Granisetron
• Grazoprevir
• Guanethidine
• Guselkumab
• Halazepam
• Haloperidol
• Halothane
• Heparin
• Hexobarbital
• Hyaluronidase
• Hydrochlorothiazide
• Hydrocodone
• Hydrocortisone
• Hydroflumethiazide
• Hydromorphone
• Hydroxytryptophan
• Hydroxyzine
• Ibuprofen
• Idelalisib
• Idrocilamide
• Ifosfamide
• Iloprost
• Imatinib
• Imipenem
• Imipramine
• Indapamide
• Indinavir
• Indomethacin
• Iobenguane I 123
• Iproniazid
• Isocarboxazid
• Isoflurane
• Isoniazid
• Itraconazole
• Ketamine
• Ketazolam
• Ketobemidone
• Ketoconazole
• Ketoprofen
• Lanreotide
• Ledipasvir
• Lepirudin
• Levalbuterol
• Levobunolol
• Levofloxacin
• Levomilnacipran
• Levonorgestrel
• Levorphanol
• Licorice
• Linezolid
• Lisdexamfetamine
• Lithium
• Lofepramine
• Lopinavir
• Lorazepam
• Lorcaserin
• Lormetazepam
• Lornoxicam
• Loxapine
• Loxoprofen
• Lumiracoxib
• Magnesium Salicylate
• Meadowsweet
• Meclizine
• Meclofenamate
• Medazepam
• Medroxyprogesterone Acetate
• Mefenamic Acid
• Melitracen
• Meloxicam
• Melperone
• Memantine
• Meperidine
• Mephenesin
• Mephobarbital
• Meprobamate
• Meptazinol
• Mesalamine
• Mesoridazine
• Mestranol
• Metaxalone
• Metformin
• Methadone
• Methamphetamine
• Methdilazine
• Methocarbamol
• Methohexital
• Methotrexate
• Methotrimeprazine
• Methoxyflurane
• Methyclothiazide
• Methyldopa
• Methylene Blue
• Methylergonovine
• Methylprednisolone
• Metildigoxin
• Metipranolol
• Metolazone
• Mexiletine
• Midazolam
• Midodrine
• Mifepristone
• Milnacipran
• Mirtazapine
• Moclobemide
• Molindone
• Moricizine
• Morniflumate
• Morphine
• Morphine Sulfate Liposome
• Nabumetone
• Nadolol
• Nadroparin
• Nalbuphine
• Naproxen
• Naratriptan
• Nateglinide
• Nefazodone
• Nelfinavir
• Nepafenac
• Netupitant
• Nialamide
• Nicomorphine
• Nicorandil
• Nifedipine
• Niflumic Acid
• Nimesulide
• Nimesulide Beta Cyclodextrin
• Nimodipine
• Nitrazepam
• Nitrous Oxide
• Norelgestromin
• Norethindrone
• Norgestimate
• Norgestrel
• Nortriptyline
• Olanzapine
• Olaparib
• Olsalazine
• Ombitasvir
• Ondansetron
• Opipramol
• Opium
• Opium Alkaloids
• Orlistat
• Orphenadrine
• Oxaprozin
• Oxazepam
• Oxprenolol
• Oxycodone
• Oxymorphone
• Oxyphenbutazone
• Oxytocin
• Palonosetron
• Panobinostat
• Papaveretum
• Paramethasone
• Parecoxib
• Paregoric
• Pargyline
• Paritaprevir
• Parnaparin
• Paroxetine
• Pefloxacin
• Peginterferon Alfa-2a
• Peginterferon Alfa-2b
• Pemetrexed
• Penbutolol
• Pentazocine
• Pentobarbital
• Pentosan Polysulfate Sodium
• Pentoxifylline
• Perampanel
• Perazine
• Periciazine
• Perphenazine
• Phenelzine
• Phenindione
• Phenobarbital
• Phenprocoumon
• Phenylbutazone
• Phenyl Salicylate
• Phenytoin
• Piketoprofen
• Pimozide
• Pindolol
• Piperacetazine
• Piperaquine
• Pipotiazine
• Piracetam
• Piritramide
• Piroxicam
• Pixantrone
• Pneumococcal 13-Valent Vaccine, Diphtheria Conjugate
• Polythiazide
• Posaconazole
• Pralatrexate
• Pranoprofen
• Prasugrel
• Prazepam
• Prednisolone
• Prednisone
• Primidone
• Procarbazine
• Prochlorperazine
• Proglumetacin
• Promazine
• Promethazine
• Propofol
• Propranolol
• Propyphenazone
• Proquazone
• Protein C
• Protriptyline
• Quazepam
• Quetiapine
• Ramelteon
• Rasagiline
• Reboxetine
• Regadenoson
• Remifentanil
• Remoxipride
• Repaglinide
• Reteplase, Recombinant
• Reviparin
• Ritonavir
• Rivaroxaban
• Rizatriptan
• Rofecoxib
• Salicylamide
• Salicylic Acid
• Salsalate
• Saquinavir
• Secobarbital
• Secukinumab
• Selegiline
• Sertindole
• Sertraline
• Sibutramine
• Simeprevir
• Sirolimus
• Sodium Oxybate
• Sodium Salicylate
• Sonidegib
• Sotalol
• Spironolactone
• St John's Wort
• Sufentanil
• Sulfasalazine
• Sulindac
• Sulpiride
• Sumatriptan
• Sunitinib
• Suvorexant
• Tacrolimus
• Tapentadol
• Telaprevir
• Telithromycin
• Temazepam
• Teniposide
• Tenofovir Alafenamide
• Tenoxicam
• Tertatolol
• Thiabendazole
• Thiethylperazine
• Thiopental
• Thiopropazate
• Thioridazine
• Tianeptine
• Tiaprofenic Acid
• Ticagrelor
• Ticlopidine
• Tilidine
• Timolol
• Tinzaparin
• Tiotropium
• Tirofiban
• Tizanidine
• Tolazamide
• Tolbutamide
• Tolfenamic Acid
• Tolmetin
• Tolonium Chloride
• Tolvaptan
• Topiramate
• Torsemide
• Tramadol
• Tranylcypromine
• Trazodone
• Treprostinil
• Triamterene
• Triazolam
• Trichlormethiazide
• Trifluoperazine
• Trifluperidol
• Triflupromazine
• Trimeprazine
• Trimipramine
• Trolamine Salicylate
• Troleandomycin
• Tryptophan
• Ulipristal
• Valdecoxib
• Varicella Virus Vaccine
• Velpatasvir
• Vemurafenib
• Venetoclax
• Venlafaxine
• Verapamil
• Vilazodone
• Vorapaxar
• Voriconazole
• Vortioxetine
• Warfarin
• Xipamide
• Zaleplon
• Zileuton
• Ziprasidone
• Zolmitriptan
• Zolpidem
• Zopiclone
• Zotepine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Using medicines in this class with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use your medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol
• Grapefruit Juice
• Tobacco

Other Medical Problems

The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcohol abuse (or history of)—Acetaminophen-containing medicines increase the chance of liver damage; also, some of the liquid medicines contain a large amount of alcohol.

• Anemia or
• Gout or
• Hemophilia or other bleeding problems or
• Stomach ulcer or other stomach problems—These conditions may become worse if you are taking a combination medicine containing aspirin or another salicylate.

• Brain disease or injury or
• Colitis or
• Convulsions (seizures) (history of) or
• Diarrhea or
• Gallbladder disease or gallstones—These conditions may become worse if you are taking a combination medicine containing codeine, dihydrocodeine, hydrocodone, or hydromorphone

• Cystic fibrosis (in children)—Side effects of iodinated glycerol may be more likely in children with cystic fibrosis.

• Diabetes mellitus (sugar diabetes)—Decongestants may put diabetic patients at greater risk of having heart or blood vessel disease.

• Emphysema, asthma, or chronic lung disease (especially in children)—Salicylate-containing medicine may cause an allergic reaction in which breathing becomes difficult.

• Enlarged prostate or
• Urinary tract blockage or difficult urination—Some of the effects of anticholinergics (e.g., homatropine) or antihistamines may make urinary problems worse.

• Glaucoma—A slight increase in inner eye pressure may occur with the use of anticholinergics (e.g., homatropine) or antihistamines, which may make the condition worse.

• Heart or blood vessel disease or
• High blood pressure—Decongestant-containing medicine may increase the blood pressure and speed up the heart rate; also, caffeine-containing medicine, if taken in large amounts, may speed up the heart rate.

• Kidney disease—This condition may increase the chance of side effects of this medicine because the medicine may build up in the body.

• Liver disease—Liver disease increases the chance of side effects because the medicine may build up in the body; also, if liver disease is severe, there is a greater chance that aspirin-containing medicine may cause bleeding.

• Thyroid disease—If an overactive thyroid has caused a fast heart rate, the decongestant in this medicine may cause the heart rate to speed up further; also, if the medicine contains narcotic antitussives (e.g., codeine), iodides (e.g., iodinated glycerol), or salicylates, the thyroid problem may become worse.

If your cough has not improved after 7 days or if you have a high fever, skin rash, continuing headache, or sore throat with the cough, check with your doctor. These signs may mean that you have other medical problems.

For patients taking a codeine-containing medicine or any other narcotic analgesics (e.g., dihydrocodeine, hydrocodone, oxycodone, and pentazocine):

• Contact your doctor immediately if you experience extreme sleepiness, confusion, or shallow breathing. These symptoms may indicate that you are an "ultra-rapid metabolizer of codeine". Ultra-rapid metabolizers change codeine to morphine more quickly and completely than other people. As a result, there is too much morphine in the body and more side effects of morphine than usual

For nursing mothers taking a codeine-containing medicine or any other narcotic cough medicine (dihydrocodeine, hydrocodone, or hydromorphone):

• Call your doctor if you become extremely tired and have difficulty caring for your baby.
• Your baby should generally nurse every two to three hours and should not sleep more than four hours at a time.
• Check with your doctor or hospital emergency room immediately if your baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, difficulty breathing, or limpness. These may be symptoms of an overdose and need immediate medical attention .

For patients taking antihistamine-containing medicine:

• Before you have any skin tests for allergies, tell the doctor in charge that you are taking this medicine. The results of the test may be affected by the antihistamine in this medicine.
• This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking this medicine.
• This medicine may cause some people to become drowsy, dizzy, or less alert than they are normally.
• Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert.
• When taking antihistamines on a regular basis, make sure your doctor knows if you are taking large amounts of aspirin at the same time (as in arthritis or rheumatism). Effects of too much aspirin, such as ringing in the ears, may be covered up by the antihistamine.
• Antihistamines may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

For patients taking decongestant-containing medicine:

• This medicine may add to the central nervous system (CNS) stimulant effects of diet aids. Do not use medicines for diet or appetite control while taking this medicine unless you have checked with your doctor.
• This medicine may cause some people to be nervous or restless or to have trouble in sleeping. If you have trouble in sleeping, take the last dose of this medicine for each day a few hours before bedtime. If you have any questions about this, check with your doctor.
• Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine.

For patients taking narcotic antitussive (codeine, dihydrocodeine, hydrocodone, or hydromorphone)-containing medicine:

• This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking this medicine.
• This medicine may cause some people to become drowsy, dizzy, less alert than they are normally, or to feel a false sense of well-being. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert and clearheaded.
• Nausea or vomiting may occur after taking a narcotic antitussive. This effect may go away if you lie down for a while. However, if nausea or vomiting continues, check with your doctor.
• Dizziness, lightheadedness, or fainting may be especially likely to occur when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem.
• Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine.

For patients taking iodide (calcium iodide, iodinated glycerol, or potassium iodide)-containing medicine:

• Make sure your doctor knows if you are planning to have any future thyroid tests. The results of the thyroid test may be affected by the iodine in this medicine.

For patients taking analgesic-containing medicine:

• Check the label of all nonprescription (over-the-counter [OTC]), and prescription medicines you now take. If any contain acetaminophen or aspirin or other salicylates, including diflunisal or bismuth subsalicylate, be especially careful. Taking them while taking a cough/cold combination medicine that already contains them may lead to overdose. If you have any questions about this, check with your health care professional.
• Do not take aspirin-containing medicine for 5 days before any surgery, including dental surgery, unless otherwise directed by your medical doctor or dentist. Taking aspirin during this time may cause bleeding problems.

For diabetic patients taking aspirin- or sodium salicylate-containing medicine:

• False urine sugar test results may occur:
  • If you take 8 or more 325-mg doses of aspirin every day for several days in a row.
  • If you take 8 or more 325-mg or 4 or more 500-mg doses of sodium salicylate.
• Smaller doses or occasional use of aspirin or sodium salicylate usually will not affect urine sugar tests. If you have any questions about this, check with your health care professional, especially if your diabetes is not well controlled.

For patients taking homatropine-containing medicine:

• This medicine may make you sweat less, causing your body temperature to increase. Use extra care not to become overheated during exercise or hot weather while you are taking this medicine since overheating may result in heat stroke. Also, hot baths or saunas may make you feel dizzy or faint while you are taking this medicine.