Humalog Mix

Name: Humalog Mix

Humalog Mix Drug Class

Humalog Mix is part of the drug classes:

  • Insulins and analogues for injection, fast acting

  • Insulins and analogues for injection, intermediate acting

  • Insulins and analogues for injection, intermediate acting combined with fast acting

Side Effects of Humalog Mix

Low blood sugar (hypoglycemia) is a side effect you should watch for while using this medication. Symptoms of low blood sugar may include:

  • sweating
  • dizziness or lightheadedness
  • shakiness
  • hunger
  • fast heart beat
  • tingling of lips and tongue
  • trouble concentrating or confusion
  • blurred vision
  • slurred speech
  • anxiety, irritability or mood changes
  • headache

Severe low blood sugar can cause unconsciousness (passing out), seizures, and death. Low blood sugar may affect your ability to drive a car or use mechanical equipment, risking injury to yourself or others. Know your symptoms of low blood sugar. Follow your healthcare provider's instructions for treating low blood sugar. Talk to your healthcare provider if low blood sugar is a problem for you.

Get medical help right away if a serious allergic reaction (whole body reaction) occurs. A rash over your whole body, trouble breathing, a fast heartbeat, or sweating are all symptoms of a whole body reaction.

Reactions at the injection site (local allergic reaction) have occurred with insulin lispro injections. You may get redness, swelling, and itching at the injection site. If you keep having skin reactions or they are serious, talk to your healthcare provider. You may need to stop using insulin lispro and use a different insulin. Do not inject insulin to skin that is red, swollen or itchy.

Another possible side effect of insulin lispro injections is skin thickening or pits at the injection site (lipodystrophy). Change (rotate) when you inject your insulin to help to prevent these skin changes from happening. Do not inject insulin into this type of skin.

Other possible side effects of insulin lispro are:

  • Swelling of your hands and feet
  • Low potassium in your blood (hypokalemia)
  • Weight gain

Inform MD

Tell your doctor:

  • about all your medical conditions, including liver or kidney problems. Your dose may need to be adjusted.
  • if you are pregnant or breastfeeding. You and your healthcare provider should talk about the best way to manage your diabetes while you are pregnant or breastfeeding. Insulin lispro has not been studied in pregnant or nursing women.
  • about all the medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Your insulin lispro dose may need to change if you take other medicines.

Humalog Mix Dosage

Take insulin lispro exactly as prescribed. Follow the directions on your prescription label carefully. Your doctor will determine the best dose for you based on several factors. 

Your dose of insulin lispro may need to be changed because of:

  • illness
  • stress
  • other medicines you take
  • change in diet
  • change in physical activity or exercise
  • travel

Do not adjust your dose unless your doctor tell you to do so. 

Humalog Mix Overdose

If you take too much insulin lispro, your blood sugar may fall low (hypoglycemia).

You can treat mild low blood sugar by drinking or eating something sugary right away (fruit juice, sugar candies, or glucose tablets).

It is important to treat low blood sugar right away because it could get worse and you could pass out (become unconscious).

If you pass out, you will need help from another person or emergency medical services right away, and will need treatment with glucagon injection or treatment at a hospital.

Other Requirements

  • Store all unopened (unused) insulin lispro in the original carton in a refrigerator at 36°F to 46°F (2°C to 8°C).
  • Do not freeze. Do not use insulin lispro if it has been frozen.
  • Keep unopened insulin lispro in the carton to protect from light.


  • Keep in the refrigerator or at room temperature below 86°F (30°C) for up to 28 days.
  • Keep vials away from direct heat or light.
  • Throw away an opened vial after 28 days of use, even if there is insulin left in the vial.
  • Unopened vials can be used until the expiration date on the insulin lispro carton and label, if the medicine has been stored in a refrigerator.

Cartridge and Prefilled Pens:

  • Keep at room temperature below 86°F (30°C) for up to 28 days.
  • Do not store a cartridge or prefilled pen that you are using in the refrigerator.
  • Keep cartridges and prefilled pens away from direct heat or light.
  • A cartridge used in the D-Tron1 or D-Tronplus1 pump may be used for up to 7 days.
  • Throw away a used cartridge or prefilled pen after 28 days, even if there is insulin left in the cartridge or the pen.